Fernando Fernando results 26
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Activation of the tail of the ventral tegmental area in response to pup predicting cues in maternal ratsNARA Subscribed
Motherhood entails brain and behavioral changes associated with increased motivation for pups, ensuring their correct development and survival. Dopamine systems play a crucial role in motivated behaviors, although the exact neurobiological mechanisms underlying maternal behavior remain unknown. The tail of the ventral tegmental area (tVTA) or rostromedial tegmental nucleus (RMTg) is a control center of dopamine systems involve...
The density of doublecortin cells in the piriform cortex is affected by transition to adulthood but not first pregnancy in miceNARA Subscribed
Motherhood is a critical period modulating behavioural changes to favour survival in mammals. In mice, olfaction is a key driver of social behaviours, and adult neurogenesis in the olfactory bulb is modulated at this stage, contributing to pup recognition. The primary olfactory cortex, known as the piriform cortex, contains a special population of neurons of embryonic origin which continues expressing immature markers such as...
The development and survival of dopaminergic neurons are influenced by the fibroblast growth factor (FGF) pathway. Anosmin-1 (A1) is an extracellular matrix protein that acts as a major regulator of this signaling pathway, controlling FGF diffusion, and receptor interaction and shuttling. In particular, previous work showed that A1 overexpression results in more dopaminergic neurons in the olfactory bulb. Prompted by those int...
A hands-on tutorial on network and topological neuroscienceNARA Subscribed
The brain is an extraordinarily complex system that facilitates the optimal integration of information from different regions to execute its functions. With the recent advances in technology, researchers can now collect enormous amounts of data from the brain using neuroimaging at different scales and from numerous modalities. With that comes the need for sophisticated tools for analysis. The field of network neuroscience has...
Preclinical studies on the effects of abrupt cessation of selective serotonin reuptake inhibitors (SSRIs), a medication often prescribed in alcohol use disorder (AUD) patients with depression, results in alcohol consumption escalation after resuming drinking. However, a potential neuroinflammatory component on this escalation remains unexplored despite the immunomodulatory role of serotonin. Here, we utilized a rat model of 14...