Global ocean warming continued unabated in 2025 in response to increased greenhouse gas concentrations and recent reductions in sulfate aerosols, reflecting the long-term accumulation of heat within the climate system, with conditions evolving toward La Niña during the year. In 2025, global upper 2000 m ocean heat content (OHC) increased by ∼23 ± 8 ZJ relative to 2024 according to IAP/CAS estimates. CIGAR-RT, and Copernicus Ma...

Heating in the ocean has continued in 2024 in response to increased greenhouse gas concentrations in the atmosphere, despite the transition from an El Niño to neutral conditions. In 2024, both global sea surface temperature (SST) and upper 2000 m ocean heat content (OHC) reached unprecedented highs in the historical record. The 0–2000 m OHC in 2024 exceeded that of 2023 by 16 ± 8 ZJ (1 Zetta Joules = 10 21 Joules, with a 95% c...

Amyotrophic lateral sclerosis (ALS)- and frontotemporal dementia (FTD)-linked mutations in CCNF have been shown to cause dysregulation to protein homeostasis. CCNF encodes for cyclin F, which is part of the cyclin F-E3 ligase complex SCF cyclinF known to ubiquitylate substrates for proteasomal degradation. In this study, we identified a function of cyclin F to regulate substrate solubility and show how cyclin F mechanistically...