Cichlid fishes have the highest rates of evolutionary turnover of sex chromosomes among vertebrates. Many large structural polymorphisms in the radiation of cichlids in Lake Malawi are associated with sex chromosomes and may also carry adaptive variation. Here, we investigate the structure and evolutionary history of an inversion polymorphism that includes both a ZW sex locus and an orange‐blotch colour polymorphism in the roc...

A crucial step in lead selection during drug development is accurate estimation and optimization of hepatic clearance using in vitro methods. However, current methods are limited by factors such as lack of physiological relevance, short culture/incubation times that are not consistent with drug exposure patterns in patients, use of drug absorbing materials, and evaporation during long-term incubation. To address these technolo...

We trapped, anesthetized, and fit 16 female feral swine ( Sus scrofa ) with Global Positioning System (GPS) collars in Great Smoky Mountains National Park (GRSM) to develop predictive summer and winter models for more effective population control efforts. Given the highly diverse habitat and topography in GRSM and the spatial extent of our dataset, we employed Step Selection Function (SSF) to evaluate resource selection at the...