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Multi-centre normative brain mapping of intracranial EEG lifespan patterns in the human brainNARA Subscribed
Understanding healthy human brain function is crucial to identify and map pathological tissue within it. Whilst previous studies have mapped intracranial EEG (icEEG) from non-epileptogenic brain regions, they often neglect age and sex effects. Further, they are limited by small sample sizes due to the modality’s invasive nature. This study substantially expands the subject pool compared to existing literature, to create a mult...
Pharmacologic profile of ITI-333: a novel molecule for treatment of substance use disordersNARA Subscribed
Rationale Medications are urgently needed to treat symptoms of drug withdrawal and mitigate dysphoria and psychiatric comorbidities that drive opioid abuse and relapse. ITI-333 is a novel molecule in development for treatment of substance use disorders, psychiatric comorbidities, and pain. Objective Characterize the preclinical profile of ITI-333 using pharmacological, behavioral, and physiological assays. Methods Cell-based a...
The London Volcanic Ash Advisory Centre (VAAC) provides forecasts on the expected presence of volcanic ash in the atmosphere to mitigate the risk to aviation. It is fundamentally important that operational capability is regularly tested through exercises, to guarantee an effective response to an event. We have developed exercises which practise the pull-through of scientific advice into the London VAAC, the forecast evaluation...
Immunoinformatic Risk Assessment of Host Cell Proteins During Process Development for Biologic TherapeuticsNARA Subscribed
The identification and removal of host cell proteins (HCPs) from biologic products is a critical step in drug development. Despite recent improvements to purification processes, biologics such as monoclonal antibodies, enzyme replacement therapies, and vaccines that are manufactured in a range of cell lines and purified using diverse processes may contain HCP impurities, making it necessary for developers to identify and quant...
OME-Zarr: a cloud-optimized bioimaging file format with international community supportNARA Subscribed
A growing community is constructing a next-generation file format (NGFF) for bioimaging to overcome problems of scalability and heterogeneity. Organized by the Open Microscopy Environment (OME), individuals and institutes across diverse modalities facing these problems have designed a format specification process (OME-NGFF) to address these needs. This paper brings together a wide range of those community members to describe t...
Fur removal promotes an earlier expression of involution-related genes in mammary gland of lactating miceNARA Subscribed
Peak lactation occurs when milk production is at its highest. The factors limiting peak lactation performance have been subject of intense debate. Milk production at peak lactation appears limited by the capacity of lactating females to dissipate body heat generated as a by-product of processing food and producing milk. As a result, manipulations that enhance capacity to dissipate body heat (such as fur removal) increase peak...
Species vary in their responses to urban habitat; most species avoid these environments, whereas others tolerate or even thrive in them. To better characterize the extent to which species vary in their responses to urban habitat (from this point forwards “urban tolerance”), we used several methods to quantify these responses at a continental scale across all birds. Using open access community science‐derived data from the eBir...
A 247‐year tree‐ring reconstruction of spring temperature and relation to spring flooding in eastern boreal CanadaNARA Subscribed
Few records of spring paleoclimate are available for boreal Canada, as biological proxies recording the beginning of the warm season are uncommon. Given the spring warming observed during the last decades, and its impact on snowmelt and hydrological processes, searching for spring climate proxies is receiving increasing attention. Tree‐ring anatomical features and intra‐annual widths were used to reconstruct the regional March...
Evaluating expert‐based habitat suitability information of terrestrial mammals with GPS‐ tracking dataNARA Subscribed
Aim Macroecological studies that require habitat suitability data for many species often derive this information from expert opinion. However, expert‐based information is inherently subjective and thus prone to errors. The increasing availability of GPS tracking data offers opportunities to evaluate and supplement expert‐based information with detailed empirical evidence. Here, we compared expert‐based habitat suitability info...
Ultrasound-induced protein restructuring and ordered aggregation to form amyloid crystalsNARA Subscribed
Amyloid crystals, a form of ordered protein aggregates documented relatively recently, have not been studied as extensively as amyloid fibres. This study investigates the formation of amyloid crystals with low frequency ultrasound (20 kHz) using β-lactoglobulin, as a model protein for amyloid synthesis. Acoustic cavitation generates localised zones of intense shear, with extreme heat and pressure that could potentially drive t...