Francesca Harris results 13
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The Holocene history of Australia's climate is surprisingly poorly understood. This is, in part, because of the relatively weak forcing of Holocene climate versus that of the late Pleistocene. However, it is commonly suggested that eastern Australia dried during the mid‐ to late‐Holocene and that this was in response to increased activity in the El Niño–Southern Oscillation (ENSO), in particular, the intensification of the El...
Spatial variation in the rocky temperate benthic mesophotic communities of the Wellington region in New ZealandNARA Subscribed
Temperate mesophotic ecosystems (TMEs) have only recently been recognised as distinct ecosystems and generally occur between 30 and 150 m at the limit of photosynthetic light penetration. In this study, we surveyed the benthic communities inhabiting rocky deep‐water features in two regions at the south of New Zealand's North Island to assess small (1–2 km) and larger (10–100 km) scale variation in the benthic communities they...
The ecology and function of rocky temperate mesophotic ecosystems (TMEs) remain poorly understood globally despite their widespread distribution. They typically occur at 20–150 m (the limit of photosynthesis), and on rocky substratum they support rich benthic communities and mobile fauna. We determined the distribution of rocky TMEs, their conservation status, and their most characteristic biological groups. Rocky TMEs were do...
From February 2020 to March 2022, four southern sea otters ( Enhydra lutris nereis ) stranded in California with severe protozoal steatitis and systemic toxoplasmosis. Three of the infected otters stranded within 26 km of each other, and all four animals died during periods of increased rainfall-driven surface water runoff. High parasite burdens were observed in all tissues except the central nervous system, and toxoplasmosis...
Obesity: a perfect storm for carcinogenesisNARA Subscribed
Obesity-related cancers account for 40% of the cancer cases observed in the USA and obesity is overtaking smoking as the most widespread modifiable risk factor for carcinogenesis. Here, we use the hallmarks of cancer framework to delineate how obesity might influence the carcinogenic hallmarks in somatic cells. We discuss the effects of obesity on (a) sustaining proliferative signaling; (b) evading growth suppressors; (c) resi...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
The marine biotoxin domoic acid (DA) is an analog of the neurotransmitter glutamate that exerts potent excitatory activity in the brain, heart, and other tissues. Produced by the diatom Pseudo-nitzschia spp., DA accumulates in marine invertebrates, fish, and sediment. Southern sea otters ( Enhydra lutris nereis ) feed primarily on invertebrates, including crabs and bivalves, that concentrate and slowly depurate DA. Due to thei...
We compiled findings from 15 years (1998–2012) of southern sea otter ( Enhydra lutris nereis ) necropsies, incorporating data from 560 animals. Sensitive diagnostic tests were used to detect biotoxins, bacteria, parasites and fungi. Methods to classify primary and contributing causes of death (COD) and sequelae utilized an updated understanding of health risks affecting this population. Several interesting patterns emerged, in...
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