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NARA Subscribed1
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Springer Nature1
Journal
Archives of Toxicology1
Publication Year
20261
Frank Edlich results 1 · Newest (Page 1/1, per page 25)
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A bovine in vitro platform improves species comparability of mitochondrial apoptosis drug-response readoutsNARA Subscribed
Archives of Toxicology · 2026 · Springer
Frederike Werry; Axel Schöniger; Annett Honak; Janett Fischer; Paula Richter; Frank Edlich
Species differences in mitochondrial apoptosis control can bias cytotoxicity endpoints and hazard-relevant mechanistic inference in preclinical test systems that rely on intrinsic-apoptosis readouts. We benchmarked steady-state localization and outer mitochondrial membrane (OMM) assemblies of the BCL-2 effectors BAX and BAK across mammals and combined this with functional apoptosis assays in bovine hepatocytes. Across species,...
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