There are five muscarinic receptor subtypes expressed in the human heart. The main subtype is the M 2 -muscarinic receptor. We hypothesized that overexpression of the M 2 -muscarinic receptor should augment any contractile effects that are M 2 -muscarinic receptor–mediated. Therefore, we generated a transgenic mouse with overexpression of the human M 2 -muscarinic receptor under the control of the heart-specific α-myosin heavy...

Summary Micro‐organisms are known to degrade a wide range of toxic substances. How the environment shapes microbial communities in polluted ecosystems and thus influences degradation capabilities is not yet fully understood. In this study, we investigated microbial communities in a highly complex environment: the capillary fringe and subjacent sediments in a hydrocarbon‐contaminated aquifer. Sixty sediment sections were analys...