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Aeromonas hydrophila is a major pathogen of Motile Aeromonad Septicemia (MAS) in Nile tilapia, with pathogenesis and immunity poorly understood. In early 2026, a > 70% mortality outbreak occurred at a Nanning tilapia farm. The dominant strain NN0116 was identified as A. hydrophila by 16S rRNA and whole‐genome ANI analysis. It exhibited high virulence (LD 50 = 5.2 × 10 3 CFU/fish). Its 5.37 Mb genome encodes 5065 proteins and c...
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