This research was to reveal the key factors in the progression of osteoarthritis (OA) using non-targeted metabolomics and to find targeted therapies for patients with OA. Twenty-two patients with knee OA scheduled for total knee arthroplasty were divided into two groups: Kellgren–Lawrence (KL) grade 3 ( n = 16) and grade 4 ( n = 6), according to plain X-rays of the knee. After the operation, the cartilages of femur samples wer...

The Tibetan Plateau (TP) is often referred to as the “water tower of Asia” or the “Third Pole”. It remains a challenge for most global and regional models to realistically simulate precipitation, especially its diurnal cycles, over the TP. This study focuses on evaluating the summer (June–August) precipitation diurnal cycles over the TP simulated by the Weather Research and Forecasting (WRF) model. The horizontal resolution us...