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Invasive fungal infections (IFI) are a significant cause of morbidity and mortality in hematologic malignancy patients and hematopoietic cell transplant (HCT) recipients. Mold cholecystitis has rarely been described. We present a case of disseminated Lomentospora prolificans , that had recrudescence of symptoms with acute cholecystitis. Treatment included a temporary cholecystostomy and administration of the novel antifungal f...
Shear Stress Initiates Endothelial-to-Mesenchymal Transition in Endocardial Endothelial CellsNARA Subscribed
Discrete subaortic stenosis (DSS) is a congenital heart disease in which a fibrotic membrane forms below the aortic valve; the underlying cellular mechanisms are currently unknown. Since an elevated pressure gradient in the left ventricular outflow tract (LVOT) is a distinguishing feature of DSS, it is hypothesized that the membrane formation is caused by elevated wall shear stress applied to the endocardial endothelial cells...
Biological shifts of endemic pearl mullet (Alburnus tarichi) during spawning migration between a highly alkaline soda lake and a riverNARA Subscribed
Lake Van is the largest lake in Türkiye (3.775 km 2 ) and the world’s largest soda lake. Pearl mullet ( Alburnus tarichi ), also known as the Van fish, is endemic to Lake Van and is accepted as an endangered species. Pearl mullet migrate from Lake Van to the freshwater streams in spring for spawning. This study aimed to investigate the responses of the antioxidant, osmoregulation, and energy metabolism and also the histologica...
Combined resistance mechanisms leading to high-level of cefiderocol resistance among NDM-like producing E. coli ST167 clinical isolatesNARA Subscribed
Summary Purpose A series of NDM-producing Escherichia coli ST167 clinical isolates exhibiting resistance to cefiderocol (FDC), with no previous exposure to this antibiotic, were analyzed in this study. Methods The antimicrobial susceptibility testing and phenotypic detection of resistance patterns (Rapid Cefiderocol NP test and MIC determination) were performed for all tested isolates. Their entire genomes were sequenced by us...
Titanium dioxide nanoparticles (TiO₂-NPs) are used widely in various industries, but emerging evidence suggests their ability to elicit neurotoxicity. The present study evaluated the alpha-lipoic acid (ALA) neuroprotective potential against TiO₂-NP-induced cognitive and molecular impairments in male Sprague–Dawley rats. Twenty-four rats were allocated into four groups: negative control, TiO₂-NPs (150 mg/kg, i.p.), ALA (50 mg/k...