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Exercise elicits mitonuclear protein imbalance and UPRmt in the liver of mice with obesityNARA Subscribed
Mitochondrial dysfunction plays a critical role in the development of metabolic dysfunction-associated steatotic liver disease (MASLD). It has been proposed that mitochondrial unfolded-protein response (UPR mt ) activation improves mitochondrial function in the liver. Growing evidence demonstrates that physical exercise effectively prevents and treats MASLD. However, the effects of exercise on UPR mt activation in the liver ar...
Energy-conserving behavioural strategies in southern right whale mother-calf pairs during early lactationNARA Subscribed
As capital breeders, baleen whale mothers fast while on the calving grounds, relying on finite energy reserves to give birth and support the rapid growth of their calves. Whereas maternal size and condition provide clear energetic advantages, the role of energy-conserving behaviours is less understood. This study aimed to examine southern right whale ( Eubalaena australis , SRW) mother-calf energy-conserving behaviours through...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Proximity to natural habitat is known to enhance pollination services in large‐scale agriculture, but it remains unclear whether this holds in tropical smallholder farms. These systems are embedded in ecologically complex landscapes, central to global food security, and depend heavily on biodiversity‐derived ecosystem services. We conducted a systematic review and meta‐analysis of 35 studies assessing the relationship between...