G. Donaldson results 44
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Theta burst stimulation (TBS) is associated with the modulation of a range of clinical, cognitive, and behavioural outcomes, but specific neurobiological effects remain somewhat unclear. This systematic literature review investigated resting-state and task-based functional magnetic resonance imaging (fMRI) outcomes post-TBS in healthy human adults. Fifty studies that applied either continuous—or intermittent—(c/i) TBS, and ado...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
Pazopanib (Votrient) is an orally administered tyrosine kinase inhibitor that blocks VEGF receptors potentially serving as anti-angiogenic treatment for hereditary hemorrhagic telangiectasia (HHT). We report a prospective, multi-center, open-label, dose-escalating study [50 mg, 100 mg, 200 mg, and 400 mg], designed as a proof-of-concept study to demonstrate efficacy of pazopanib on HHT-related bleeding, and to measure safety....
Over the past 20 years, there has been a dramatic increase in the use of physiological tools and experimental approaches for the study of the biological consequences of catch‐and‐release angling practices for fishes. Beyond simply documenting problems, physiological data are also being used to test and refine different strategies for handling fish such that stress is minimised and survival probability maximised, and in some ca...
The role of temperature in the capture and release of fishNARA Subscribed
We searched major electronic databases to identify peer‐reviewed literature investigating the role of temperature on the stress response and mortality of captured and released fish. We identified 83 studies that fit these criteria, the majority of which were conducted in North America (81%) on freshwater fish (76%) in the orders Perciformes (52%) and Salmoniformes (28%). We found that hook‐and‐line fisheries (65% of all studie...
Prompted by the dramatic increase in the use of blood analyses in fisheries research and monitoring, this study investigated the efficacy of common field techniques for sampling and storing blood from fishes. Three questions were addressed: (1) Do blood samples taken via rapid caudal puncture (the ‘grab‐and‐stab’ technique) yield similar results for live v. sacrificed groups of fishes? (2) Do rapidly obtained caudal blood samp...
Effects of different capture techniques on the physiological condition of bonefish Albula vulpes evaluated using field diagnostic toolsNARA Subscribed
A study was conducted on bonefish Albula vulpes in The Bahamas to assess the utility of portable physiological diagnostic tools (i‐STAT analyser with E3+ ion and haematology cartridge, ACCU‐CHEK glucose meter and Lactate Pro lactate meter) for field physiology applications in remote locations. Physiological values derived from portable diagnostic tools were significantly related to values obtained from standard laboratory tech...
Using spatial predictions of future threats to biodiversity, we assessed for the first time the relative potential impacts of future land use and climate change on the threat status of plant species. We thus estimated how many taxa could be affected by future threats that are usually not included in current IUCN Red List assessments. Here, we computed the Red List status including future threats of 227 Proteaceae taxa endemic...
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