G. FLORIO results 21
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Arterial aging is associated with enhanced angiotensin II (Ang II) signaling via Ang II type 1 receptor (AT1R) and with microRNA-34a (miR-34a) increased expression. AT1R-associated protein (ATRAP/Agtrap) binds to AT1R, promotes its internalization, and inhibits Ang II signaling. This study addresses the hypothesis that miR-34a targets ATRAP/Agtrap and enhances Ang II pro-inflammatory signaling via AT1R in arterial vascular smo...
Therapeutic Reference Range for Aripiprazole in Schizophrenia Revised: a Systematic Review and MetaanalysisNARA Subscribed
Rationale While one of the basic axioms of pharmacology postulates that there is a relationship between the concentration and effects of a drug, the value of measuring blood levels is questioned by many clinicians. This is due to the often-missing validation of therapeutic reference ranges. Objectives Here, we present a prototypical meta-analysis of the relationships between blood levels of aripiprazole, its target engagement...
Charcot-Marie-Tooth disease type 1A (CMT1A), caused by duplication of the peripheral myelin protein 22 ( PMP22 ) gene, and CMT1B, caused by mutations in myelin protein zero ( MPZ ) gene, are the two most common forms of demyelinating CMT (CMT1), and no treatments are available for either. Prior studies of the Mpz Ser63del mouse model of CMT1B have demonstrated that protein misfolding, endoplasmic reticulum (ER) retention and a...
This study provides information on bathymetric and longitudinal distribution heterogeneity of the rockfish Helicolenus dactylopterus in the southern Tyrrhenian Sea. Data were drawn from experimental bottom trawl (1996-2002) plus bottom trap (2001-02) surveys. The frequency of occurrence and mean relative density (N/km2) and biomass (kg/km2) indexes were calculated for two survey seasons (spring and autumn), four geographic sec...
Occurrence of Mycobacterium spp. in ornamental fish in ItalyNARA Subscribed
The occurrence of Mycobacterium spp. in freshwater and marine ornamental fish was studied in Italy from June 2002 to May 2005. Two surveys were carried out, one of aquarium fish sent to the Laboratory for diagnosis, and the other of prevalence of infection by mycobacteria in ornamental fish imported into Italy. Bacterial isolation was carried out from the spleen, kidney and liver, and the isolates were subsequently identified...
The slipper lobster, Scyllarides latus (Latreille, 1803), is the only representative species of the genusScyllarides in the Mediterranean Sea. In this study, we examined some biological aspects of this species sampled in the Straits of Messina. The specimens were sexed, measured and weighed. The relationships between body measurements (length and width of the carapace, antennal length) and length-weight relationship were calcu...
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