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Antibody–drug conjugates (ADCs) represent a rapidly evolving therapeutic modality, combining the selective targeting of monoclonal antibodies with highly potent small molecule payloads. Their inherent structural complexity demands a sophisticated and multi-faceted bioanalytical approach spanning preclinical discovery through late-stage clinical development. This white paper, developed by the ADC Working Group of the AAPS bioan...
Stomatal Decoupling From Photosynthesis Under High Temperatures Is Consistent With Stomatal OptimisationNARA Subscribed
Stomatal pores on plant leaves regulate the gain of carbon through photosynthesis and the loss of water through transpiration. Through their responses to environmental conditions, stomata can constrain plant productivity and transpiration fluxes, exerting a strong control on climate feedbacks over land. Although mechanistic modelling of stomata remains a challenge, semi‐empirical and optimisation models have been successfully...
Precision measurement of the Ds*+-Ds+ meson mass differenceNARA Subscribed
Monitoring evapotranspiration to link agricultural water use with crop yield at sub-field scalesNARA Subscribed
Purpose Scientists and producers have pursued precision agriculture to increase yields and limit environmental impacts. Applying precision agriculture concepts has not been straightforward, however, because complex interactions between soil and weather govern crop growth. We hypothesize that evapotranspiration (ET) is a single metric that captures interactions between plant status, soil, topography, and weather and can be used...
Discovery of a Potent Small Molecule Antagonist of GRPR for the Treatment of PruritusNARA Subscribed
Persistent pruritus (itch) affects the quality of life, and many itch syndromes remain untreatable. Previously, we identified the gastrin-releasing peptide receptor (GRPR) playing a critical role in mediating histamine-independent itch signaling. In this study, we aimed to identify small-molecule GRPR antagonists to treat histamine-independent itch. Starting with the known small-molecule GRPR antagonist PD 176,252, we conducte...
A machine learning framework for California vineyard water status monitoring using sUAS Imagery and short-term meteorological dataNARA Subscribed
Efficient irrigation management is essential for sustainable crop production under increasing temperatures and tightening water supplies. In vineyards, water status significantly influences vine growth, yield, and fruit quality, and deficit irrigation is often used to impose controlled stress while avoiding damaging levels of water limitation. This creates a practical need for routine, field-scale monitoring of vine water stat...
Distributed optical fibre sensing (DOFS) is a technology that enables continuous, real-time measurements of a range of environmental parameters along the length of a fibre optic cable. In this article, we review the recently emerged applications of DOFS techniques in physical oceanography and offer a perspective on the technology's potential for future growth within the field. The introduction of DOFS to physical oceanography...