Introduction The unbound brain-to-plasma partition coefficient (K p,uu,BBB ) is an essential parameter for predicting central nervous system (CNS) drug disposition using physiologically-based pharmacokinetic (PBPK) modeling. K p,uu,BBB values for specific compounds are however often unavailable, and are moreover time consuming to obtain experimentally. The aim of this study was to develop a quantitative structure–property rela...

Diffusive boundary layers, photosynthesis, and respiration in Phaeocystis colonies were studied by the use of microelectrodes for oxygen and pH during a bloom in the Barents Sea, 1993, and in the Marsdiep, Dutch North Sea, 1994. The oxygen microenvironment of a Phaeocystis colony with a mean diameter of 1.4 mm was mapped from 346 O2 measurements and showed gradients of oxygen concentration in the water phase up to 1 mm distanc...