Increasing life expectancy has been accompanied by a higher prevalence of age-associated conditions, underscoring the need to better understand biological mechanisms of aging and to identify accessible biomarkers. Extracellular vesicles (EVs) are lipid-bilayer vesicles that mediate intercellular communication by transporting proteins, lipids, and regulatory RNAs, including microRNAs (miRNAs). Here, we investigated whether the...

This study documents the lifecycle and large-scale environment of a large-hail producing supercell that occurred in southern Brazil (SB) on 6 October 2015. The supercell underwent a merger with a nascent supercell near a Doppler weather radar and rapidly intensified shortly after the interaction. The original (premerger) supercell developed in a high-shear, high-instability pre-cyclogenesis environment and remained isolated un...

L-DOPA (LD) is the gold-standard treatment of motor symptoms in Parkinson’s disease (PD), conventionally used to prove the predictive value of PD animal models. This study aimed to investigate the predictive validity of an adaptation of the conventional reserpine model of PD: the repeated low-dose reserpine administration in rodents, which promotes progressive motor impairment in catalepsy, vacuous chewing behavior tests, and...

Cell fate determination and terminal differentiation are shaped by intrinsic molecular programs that coordinate lineage-specific gene expression. In mesenchymal stem cells (MSCs), variability in osteogenic efficiency among distinct tissue sources remains poorly understood and cannot be fully explained by differentiation conditions alone. Increasing evidence indicates that post-transcriptional regulatory mechanisms, particularl...

Quantifying biotic interactions at scale is critical to understanding ecosystem functions, such as plant‐pollinator interactions. Here, we demonstrate how woody plant functional traits and vegetation structure gathered with remote sensing can aid in predicting plant‐pollinator network indices from fine to broad spatial extents. We analysed 209 tropical plant‐pollinator networks, where vegetation characteristics were generated...

The incidence of brain diseases increases with aging, but the biological basis of brain aging is still poorly explored. Synaptic dysfunction occurs at the onset of brain diseases and synaptic neuromodulation systems, such as adenosine A 2A receptors (A 2A R), are necessary and sufficient to trigger brain dysfunction. Since A 2A R are upregulated upon aging, we compared wild-type and A 2A R global knockout mice to test if brain...

This study assessed the functional potential of autochthonous lactic acid bacteria isolated from the gastrointestinal tract of tambaqui ( Colossoma macropomum ) as larviculture probiotics. Five strains were selected and identified as belonging to the genus Weissella . In vitro assays revealed high tolerance to acidic pH (2.0–3.0), resistance to bile salts (10%), biofilm formation capacity, hydrophobicity and direct Aeromonas h...