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Context matters: emotional responses to urban greening interventions depend on city settingNARA Subscribed
Urban green spaces deliver a remarkable range of human health and well-being benefits, and there is substantial, global effort into incorporating urban greening into the design of cities. However, intense competition for space in cities means small interstitial gaps in the urban fabric are being used for many contemporary green spaces, such as planter boxes or raised garden beds. These small urban greening interventions have b...
Purpose Examine which demographic, lifestyle, and clinical risk factors differ between patients with early-onset colorectal cancers (EOCRC) compared to late-onset colorectal cancers (LOCRC). Methods We conducted a case-case comparison of risk factors and symptoms for EOCRC and LOCRC, utilizing the Ohio Colorectal Cancer Prevention Initiative (OCCPI) data, a statewide study of newly diagnosed CRC among Ohio residents, aged 20–9...
Introduction Insufficiency of the future liver remnant (FLR) precludes surgery for liver tumors as it is associated with post-hepatectomy liver failure (PHLF). A common strategy to induce pre-operative FLR hypertrophy is portal vein embolization of the tumor bearing liver lobe. More recently, transarterial radio-embolization (radiation lobectomy, RL) has been employed. Direct functional assessment using 99mTc-mebrofenin-hepato...
Marine megafauna species are affected by a wide range of anthropogenic threats. To evaluate the risk of such threats, species’ vulnerability to each threat must first be determined. We build on the existing threats classification scheme and ranking system of the International Union for Conservation of Nature (IUCN) Red List of Threatened Species by assessing the vulnerability of 256 marine megafauna species to 23 at‐sea threat...
The Effect of Viscous Dissipation on the Darcy–Bénard Problem: Weakly Nonlinear Analysis and Strongly Nonlinear ComputationsNARA Subscribed
We consider the effect of viscous dissipation on the onset and nonlinear development of two-dimensional convection in a unit enclosure heated from below. First, we show that the linear theory is unchanged from that which arises when viscous dissipation is absent. Second, a weakly nonlinear analysis shows that convection becomes weaker with increasing values of $${\widetilde{\textrm{Ge}}}$$ Ge ~ , a modified Gebhart number. In...
Patterns and Drivers of Phylogenetic Beta Diversity in the Forests and Savannas of AfricaNARA Subscribed
Aim Studying beta diversity, or the variation in species composition among communities, can give insights into plant community assembly over space and time. If different biomes show contrasting large‐scale beta‐diversity patterns, this can indicate divergent evolutionary histories or ecological processes that then drive species turnover among communities. Here, we examine phylogenetic beta‐diversity patterns across Africa in f...
A Transcriptomic Comparative Study of Cranial VasculatureNARA Subscribed
Genetic toxicity testing assesses the potential of compounds to cause DNA damage. There are many genetic toxicology screening assays designed to assess the DNA damaging potential of chemicals in early drug development aiding the identification of promising drugs that have low-risk potential for causing genetic damage contributing to cancer risk in humans. Despite this, in vitro tests generate a high number of misleading positi...
Can nitrogen input mapping from aerial imagery improve nitrous oxide emissions estimates from grazed grassland?NARA Subscribed
Most nitrogen (N) lost to the environment from grazed grassland is produced as a result of N excreted by livestock, released in the form of nitrous oxide (N 2 O) emissions, nitrate leaching and ammonia volatilisation. In addition to the N fertiliser applied, excreta deposited by grazing livestock constitute a heterogeneous excess of N, creating spatial hotspots of N losses. This study presents a yearlong N 2 O emissions map fr...
The world’s largest extant fish, the whale shark Rhincodon typus , is one of the most-studied species of sharks globally. The discovery of predictable aggregation sites where these animals gather seasonally or are sighted year-round – most of which are coastal and juvenile-dominated – has allowed for a rapid expansion of research on this species. The most common method for studying whale sharks at these sites is photographic i...
This position paper summarizes the current understanding of biological nitrification inhibition (BNI) to identify research needs for accelerating the development of BNI as a N 2 O mitigation strategy for grazed livestock systems. We propose that the initial research focus should be on the systematic screening of agronomically desirable plants for their BNI potency and N 2 O reduction potential. This requires the development of...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
Inter-laboratory automation of the in vitro micronucleus assay using imaging flow cytometry and deep learningNARA Subscribed
The in vitro micronucleus assay is a globally significant method for DNA damage quantification used for regulatory compound safety testing in addition to inter-individual monitoring of environmental, lifestyle and occupational factors. However, it relies on time-consuming and user-subjective manual scoring. Here we show that imaging flow cytometry and deep learning image classification represents a capable platform for automat...
Pathogen infection influences a distinct microbial community composition in sorghum RILsNARA Subscribed
Aims The rhizosphere microbiome substantially affects plant health, yet comparatively little is known regarding the foliar community dynamics. Here, we examine the relationship between the microbiota and their response to natural infection by pathogens. Methods We established an experimental system using a set of sorghum recombinant inbred lines (RILS). These RILS included four models denoted as resistant, moderately resistant...
The flow (flux) of climate-critical gases, such as carbon dioxide (CO2), between the ocean and the atmosphere is a fundamental component of our climate and an important driver of the biogeochemical systems within the oceans. Therefore, the accurate calculation of these air–sea gas fluxes is critical if we are to monitor the oceans and assess the impact that these gases are having on Earth's climate and ecosystems. FluxEngine i...