Mathematical and statistical models underlie many of the world's most important fisheries management decisions. Since the 19th century, difficulty calibrating and fitting such models has been used to justify the selection of simple, stationary, single‐species models to aid tactical fisheries management decisions. Whereas these justifications are reasonable, it is imperative that we quantify the value of different levels of mod...

Most protected area impact research that uses counterfactuals draws heavily on quantitative methods, data, and knowledge types, making it valuable in producing generalizations but limited in temporal scope, historical detail, and habitat diversity and coverage of ecosystem services. We devised a methodological pluralistic approach, which supports social science qualitative methods, narratives, mixed methods, and interdisciplin...

While there has been rapid advancement in the development and application of statistical downscaling methods for climate projection, determining the best predictive large‐scale climate information for the targeted local climate variable remains a challenge. The choice of predictor variables is one of the most influential steps of model development and has the potential to lead to varying results, contributing to the total unce...

The significance of the southern Caucasus in understanding Pleistocene hominin expansions is well established. However, the palaeoenvironments in which Palaeolithic occupation of the region took place are presently poorly defined. The Hrazdan river valley, Armenian Highlands, contains a rich Palaeolithic record alongside Middle Pleistocene volcanic, fluvial and lacustrine strata, and thus offer exciting potential for palaeoenv...

Several neonicotinoids have recently been shown to activate the nicotinic acetylcholine receptor (nAChR) on human neurons. Moreover, imidacloprid (IMI) and other members of this pesticide family form a set of diverse metabolites within crops. Among these, desnitro-imidacloprid (DN-IMI) is of special toxicological interest, as there is evidence (i) for human dietary exposure to this metabolite, (ii) and that DN-IMI is a strong...

The native vs. exotic status of reed canarygrass (RCG), a major invasive species of Minnesota wetlands, is unknown. The aim of this study was to investigate this native vs. exotic status to enhance its management. Genetic comparison of wild RCG populations from six Minnesota and six Czech Republic rivers was performed. A total of 2521 polymorphic SNP markers (single nucleotide polymorphisms) were used to evaluate 478 RCG sampl...

Neonicotinoid pesticides, originally developed to target the insect nervous system, have been reported to interact with human receptors and to activate rodent neurons. Therefore, we evaluated in how far these compounds may trigger signaling in human neurons, and thus, affect the human adult or developing nervous system. We used SH-SY5Y neuroblastoma cells as established model of nicotinic acetylcholine receptor (nAChR) signali...

Three clearly defined abrupt cooling events (ACEs) can be observed within Greenland Interstadial (GI)‐1 in the Greenland ice‐core records. However, the spatial variation in amplitude and timing of these ACEs is poorly understood due to the paucity of well‐dated records with quantified temperature reconstructions. This study presents high‐resolution chironomid‐inferred July air temperature (T Jul ) and oxygen isotope (δ 18 O) r...

The influence of the North Atlantic on the margins of Europe means the region is particularly sensitive to changes in the ocean–atmospheric system. During the Last Glacial–Interglacial Transition (16–8 cal ka bp ) this system was repeatedly disrupted, leading to a series of abrupt and short‐lived shifts in climate. Despite much research, the number and magnitude of these ‘centennial‐scale’ events is not well understood. To add...

Spinocerebellar ataxia type 14 (SCA-PRKCG, formerly SCA14) is a rare, slowly progressive disorder caused by conventional mutations in protein kinase Cγ (PKCγ). The disease usually manifests with ataxia, but previous reports suggested PRKCG variants in retinal pathology. To systematically investigate for the first time visual function and retinal morphology in patients with SCA-PRKCG. Seventeen patients with PRKCG variants and...

Sea level is one of the 50 Essential Climate Variables (ECVs) listed by the Global Climate Observing System (GCOS) in climate change monitoring. In the past two decades, sea level has been routinely measured from space using satellite altimetry techniques. In order to address a number of important scientific questions such as "Is sea level rise accelerating?", "Can we close the sea level budget?", "What are the causes of the r...