G.R. Sutherland results 36
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One species does not replace a community: functional roles of co-occurring translocated and endemic mycophagous mammalsNARA Subscribed
Biodiversity decline alters species interaction networks and can destabilise ecosystem functions. Fungal consumption by mammals supports ectomycorrhizal (ECM) spore dispersal, contributing to fungi-plant symbioses. The ecological impacts of losing mycophagous mammals and to what extent species roles are redundant or complementary remains poorly quantified. Using fungal ITS2 metabarcoding, we explore the fungal community in sca...
Mycophagy varies at individual-, population- and site- levels in the diet of a translocated mammal across multiple safe havensNARA Subscribed
Restoring ecosystem functions via conserving and translocating threatened species is an increasingly common conservation action and priority. Monitoring how a translocated species interacts with the recipient ecosystem and co-occurring species is rarely the focus of strategic management plans. Digging, mycophagous mammals play critical ecosystem roles including bioturbation and fungal spore dispersal. The fungal diets of trans...
High mortality rates of cultured Pacific oysters ( Crassostrea gigas ) during the summer months have regularly occurred on oyster farms in British Columbia, Canada over the last 10 years, but little is known about the microbial and environmental conditions that contribute to such mortality events. The objective of the study was to determine correlative factors associated with the onset of a summer mortality event in oysters (m...
Tropical rock lobsters (Panulirus ornatus) are a highly cannibalistic species with intermoult animals predominantly attacking animals during ecdysis (moulting). Rapid, positive characterisation of pre-ecdysis lobsters may open a pathway to disrupt cannibalism. Ecdysial suture line development is considered for pre-ecdysis recognition with suture line definition compared for intermoult and pre-ecdysis lobsters emerged and immer...
Exonic mutations in cell–cell adhesion may contribute to CADASIL-related CSVD pathologyNARA Subscribed
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a condition caused by mutations in NOTCH3 and results in a phenotype characterised by recurrent strokes, vascular dementia and migraines. Whilst a genetic basis for the disease is known, the molecular mechanisms underpinning the pathology of CADASIL are still yet to be determined. Studies conducted at the Genomics Research C...
Investigating a Genetic Link Between Alzheimer’s Disease and CADASIL-Related Cerebral Small Vessel DiseaseNARA Subscribed
Monogenic forms of Alzheimer’s disease (AD) have been identified through mutations in genes such as APP, PSEN1, and PSEN2 , whilst other genetic markers such as the APOE ε carrier allele status have been shown to increase the likelihood of having the disease. Mutations in these genes are not limited to AD, as APP mutations can also cause an amyloid form of cerebral small vessel disease (CSVD) known as cerebral amyloid angiopat...
Investigation of Mitochondrial Related Variants in a Cerebral Small Vessel Disease CohortNARA Subscribed
Monogenic forms of cerebral small vessel disease (CSVD) can be caused by both variants in nuclear DNA and mitochondrial DNA (mtDNA). Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) is known to have a phenotype similar to Cerebral Autosomal Dominant Arteriopathy with Sub-cortical Infarcts and Leukoencephalopathy (CADASIL), and can be caused by variants in the mitochondrial genome and in several n...
Geographical contrasts of Y‐chromosomal haplogroups from wild and domestic goats reveal ancient migrations and recent introgressionsNARA Subscribed
By their paternal transmission, Y‐chromosomal haplotypes are sensitive markers of population history and male‐mediated introgression. Previous studies identified biallelic single‐nucleotide variants in the SRY , ZFY and DDX3Y genes, which in domestic goats identified four major Y‐chromosomal haplotypes, Y1A, Y1B, Y2A and Y2B, with a marked geographical partitioning. Here, we extracted goat Y‐chromosomal variants from whole‐gen...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
With the accelerating pace of global change, it is imperative that we obtain rapid inventories of the status and distribution of wildlife for ecological inferences and conservation planning. To address this challenge, we launched the SNAPSHOT USA project, a collaborative survey of terrestrial wildlife populations using camera traps across the United States. For our first annual survey, we compiled data across all 50 states dur...
Prioritization of knowledge‐needs to achieve best practices for bottom trawling in relation to seabed habitatsNARA Subscribed
Management and technical approaches that achieve a sustainable level of fish production while at the same time minimizing or limiting the wider ecological effects caused through fishing gear contact with the seabed might be considered to be ‘best practice’. To identify future knowledge‐needs that would help to support a transition towards the adoption of best practices for trawling, a prioritization exercise was undertaken wit...
Prioritization of knowledge needs for sustainable aquaculture: a national and global perspectiveNARA Subscribed
Aquaculture is currently the fastest expanding global animal food production sector and is a key future contributor to food security. An increase in food security will be dependent upon the development and improvement of sustainable practices. A prioritization exercise was undertaken, focusing on the future knowledge needs to underpin UK sustainable aquaculture (both domestic and imported products) using a ‘task force’ group o...
Divergent immunity and energetic programs in the gills of migratory and resident O ncorhynchus mykissNARA Subscribed
Divergent life history strategies occur in steelhead or rainbow trout O ncorhynchus mykiss , and many populations produce both migrant (anadromous fish that move to the ocean after rearing) and resident (do not migrate and remain in fresh water) individuals. Mechanisms leading to each type are only partially understood; while the general tendency of a population is heritable, individual tendency may be plastic, influenced by l...
Priority research questions for the UK food systemNARA Subscribed
The rise of food security up international political, societal and academic agendas has led to increasing interest in novel means of improving primary food production and reducing waste. There are however, also many ‘post-farm gate’ activities that are critical to food security, including processing, packaging, distributing, retailing, cooking and consuming. These activities all affect a range of important food security elemen...
BDNF and TNF-α polymorphisms in memoryNARA Subscribed
Transcriptomics of coping strategies in free‐swimming Lepeophtheirus salmonis (Copepoda) larvae responding to abiotic stressNARA Subscribed
The salmon louse Lepeophtheirus salmonis is a marine ectoparasite of wild and farmed salmon in the Northern Hemisphere. Infections of farmed salmon are of economic and ecological concern. Nauplius and copepodid salmon lice larvae are free‐swimming and disperse in the water column until they encounter a host. In this study, we characterized the sublethal stress responses of L. salmonis copepodid larvae by applying a 38K oligonu...