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Regional ecosophy: a Guattarian approach to the border landscapes of the Irish NorthwestNARA Subscribed
In this paper, we propose that landscape architecture is uniquely equipped to shape highly contested and politicized border regions. We contend that recognizing landscape architecture’s agency to contribute to national and international politics may enable the field to intervene in contemporary theoretical discussions within urban and regional studies that are otherwise dominated by geography and urban planning. Through the ex...
Pharmacological inhibition of MERTK induces in vivo retinal degeneration: a multimodal imaging ocular safety assessmentNARA Subscribed
The receptor tyrosine kinase, MERTK, plays an essential role in homeostasis of the retina via efferocytosis of shed outer nuclear segments of photoreceptors. The Royal College of Surgeons rat model of retinal degeneration has been linked to loss-of-function of MERTK, and together with the MERTK knock-out mouse, phenocopy retinitis pigmentosa in humans with MERTK mutations. Given recent efforts and interest in MERTK as a potent...
Current in vitro genotoxicity tests can produce misleading positive results, indicating an inability to effectively predict a compound’s subsequent carcinogenic potential in vivo. Such oversensitivity can incur unnecessary in vivo tests to further investigate positive in vitro results, supporting the need to improve in vitro tests to better inform risk assessment. It is increasingly acknowledged that more informative in vitro...
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