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NARA Subscribed1
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Springer Nature1
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Journal of Muscle Research and Cell Motility1
Publication Year
20231
Georgia Atkinson results 1 · Newest (Page 1/1, per page 25)
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Zebrafish as a model for cardiac disease; Cryo-EM structure of native cardiac thin filaments from Danio RerioNARA Subscribed
Journal of Muscle Research and Cell Motility · 2023 · Vol. 44 · Issue 3 · Springer
Marston Bradshaw; John M. Squire; Edward Morris; Georgia Atkinson; Rebecca Richardson; Jon Lees; Massimo Caputo; Giulia M. Bigotti; Danielle M. Paul
Actin, tropomyosin and troponin, the proteins that comprise the contractile apparatus of the cardiac thin filament, are highly conserved across species. We have used cryo-EM to study the three-dimensional structure of the zebrafish cardiac thin and actin filaments. With 70% of human genes having an obvious zebrafish orthologue, and conservation of 85% of disease-causing genes, zebrafish are a good animal model for the study of...
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