Rheumatoid arthritis (RA) is an autoimmune disease with an intriguing pathophysiological mechanism that primarily affects the joints and leads to extra-articular manifestations. Leflunomide is one of the most effective disease-modifying anti-rheumatic drugs (DMARDs), utilized in RA treatment, but its use comes with frequent gastrointestinal adverse effects, which might necessitate therapy discontinuation. The current work aime...

Olmesartan medoxomil (OLM), a widely prescribed antihypertensive agent, suffers from poor solubility and first pass metabolism, which lowers its bioavailability. This work aimed to develop novel cationic nanocarriers (LeciPlex) for OLM to enhance its dissolution and oral bioavailability. A central composite design (CCD) was employed to optimize OLM-loaded LeciPlex (OLM-LPX) formulations. The independent variables included leci...

Accurate monitoring of chlorophyll-a (Chl-a) is critical for assessing eutrophication and water quality in inland aquatic ecosystems. While integrating Sentinel-2 MultiSpectral Instrument (MSI) imagery with machine learning (ML) is widely used for water quality assessment, challenges remain in optimizing Chl-a retrieval in optically complex small-scale reservoirs, particularly in semi-arid environments where traditional models...

Aquaculture has been rapidly growing during the past decade to accommodate the increasing need for seafood as a vital source of nutrients for human beings. The nutritional benefits of incorporating fish into one’s diet are paramount in promoting overall health, bolstering immunity and warding off diseases. Nonetheless, farm-raised aquatic species are frequently subjected to elevated contamination levels due to pesticides, anti...

This exploration focuses on the removal of chromium from actual tannery wastewater, collected from the HARBY TANNERY factory in Rubiki (Badr City), using an economical sorbent made from activated carbon derived from rice straw (CRS). The CRS sorbent is activated using H 3 PO 4 . The experiment aims to assess the impact of various parameters, including chromium initial concentration, sorbent dosage, treatment time, agitation ve...

Nanometric titanium derivatives such as hydroxide and dioxide compounds have a great attention because they are significant industrial material of commercial importance and applications in photocatalyst, semiconductors, and wastewater treatment. The present investigation gives the results of anodic dissolution preparation of titanium hydroxide nanometric particles followed by calcination for complete conversion to nanometric t...