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Supercritical fluid (SCF)-assisted preparation of cyclodextrin-based poly(pseudo)rotaxanes for transdermal purposesNARA Subscribed
This study aims to investigate the effect of the preparation of solid dispersions using supercritical CO 2 (scCO 2 ) on the physicochemical properties and the performance of supramolecular gels based on polymer-cyclodextrin (CD) interactions (named poly(pseudo)rotaxanes, PPR) envisaging a transdermal administration. Solid dispersions containing Soluplus ® , the antihypertensive drug carvedilol (CAR), and CD (αCD or HPβCD) were...
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