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Springer Nature1
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Human Cell1
Publication Year
20251
Grace Needham results 1 · Newest (Page 1/1, per page 25)
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Role of hepatocellular senescence in the development of hepatocellular carcinoma and the potential for therapeutic manipulationNARA Subscribed
Human Cell · 2025 · Vol. 38 · Issue 3 · Springer
Pramudi Wijayasiri; Stuart Astbury; Grace Needham; Philip Kaye; Mamatha Bhat; Anna M. Piccinini; Aloysious D. Aravinthan
Accumulation of senescent hepatocytes is universal in chronic liver disease (CLD). This study investigates an association between hepatocyte senescence and hepatocellular carcinoma (HCC) and explores the therapeutic role of sirolimus. Background liver biopsies from 15 patients with cirrhosis and HCC and 45 patients with cirrhosis were stained for p16, a marker of cell senescence. STAM™ mice were randomized into 3 groups of 5 a...
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