Purpose This study aimed to investigate bilateral motor control and connectivity between supplementary motor area (SMA) and primary motor cortex (M1) in younger, middle-aged, and older healthy adults. Methods 32 younger (mean age 22.8 ± 5.3 years), 18 middle-aged (47.6 ± 6.5 years), and 23 older (75.8 ± 6.7 years) adults were tested. Bilateral motor control was assessed using the Purdue pegboard. Dual-site transcranial magneti...

Organismal aging has been associated with diverse metabolic and functional changes across tissues. Within the immune system, key features of physiological hematopoietic cell aging include increased fat deposition in the bone marrow, impaired hematopoietic stem and progenitor cell (HSPC) function, and a propensity towards myeloid differentiation. This shift in lineage bias can lead to pre-malignant bone marrow conditions such a...

Purpose Unilateral strength training may attenuate the decline in muscle strength and size in homologous, contralateral muscles. This study aimed to determine whether the cross-education of strength could specifically attenuate the effects of detraining immediately after a short (prehabilitation-type) period of strength training. Methods Twenty-six strength-trained participants were assigned to either four weeks of unilateral...