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Peripheral microRNA signature in genetic frontotemporal dementia—findings from the GENFI initiativeNARA Subscribed
Frontotemporal dementia (FTD) is a neurodegenerative disease characterized by significant clinical and genetic heterogeneity, with approximately 40% of cases linked to hereditary genetic mutations, including MAPT , GRN , and C9ORF72 . Recently, microRNAs (miRNAs) have emerged as key regulators of cellular processes related to neurodegeneration and as potential biomarkers for FTD. However, their relevance in presymptomatic stag...
Seagrasses have been entwined with human culture for millennia, constituting a natural resource that has supported humanity throughout this history. Understanding the societal value of seagrass fosters appreciation of these ecosystems, encouraging conservation and restoration actions to counteract historic and predicted losses. This study overviews the plethora of seagrass use in human history, ranging from spiritual and cerem...
Animal telemetry is maturing into a viable method for observing the ocean as it can be used to monitor both environmental conditions and biological metrics along the movement trajectories of marine animals. As part of the Cormorant Oceanography Project, we have augmented a biologging tag with an external fast response temperature sensor to collect ocean temperature profiles from the backs of foraging marine birds. Cormorants d...
Spatial pattern of seed arrival has a greater effect on plant diversity than does soil heterogeneity in a grassland ecosystemNARA Subscribed
Background and Aims Species diversity is expected to increase with environmental heterogeneity. For plant communities, this pattern has been confirmed by numerous observational studies. Yet, experimental studies yield inconsistent results potentially because of how experiments create soil heterogeneity or because seeds were sown homogeneously. Using a field experiment, we tested how soil heterogeneity, plant spatial aggregatio...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
Aim We investigated the effects of disease on the local abundances and distributions of species at continental scales by examining the impacts of white‐nose syndrome, an infectious disease of hibernating bats, which has recently emerged in N orth A merica. Location N orth A merica and E urope. Methods We used four decades of population counts from 1108 populations to compare the local abundances of bats in N orth A merica befo...
Global change is impacting forests worldwide, threatening biodiversity and ecosystem services including climate regulation. Understanding how forests respond is critical to forest conservation and climate protection. This review describes an international network of 59 long‐term forest dynamics research sites ( CTFS ‐Forest GEO ) useful for characterizing forest responses to global change. Within very large plots (median size...
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