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Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Oyster Size Distributions Vary Across Time and Space in the Tampa Bay Estuary, 250–2024 ceNARA Subscribed
Aim Restoration benchmarks often assume an undisturbed historic range of variability, if they include historic information at all. However, recent research highlights the need for a more nuanced understanding of shifting baselines and how to best incorporate past variabilities in modern management. We investigate trends in oyster size through time (ca. 250–2024 ce ) and space (ca. 1000 km 2 ) in the Tampa Bay Estuary to unders...
Clinician Perspectives on the Implementation of a Web-Based Tool to Support Shared Decision-Making for Mid-Adult HPV VaccinationNARA Subscribed
In 2019, the U.S. Advisory Committee on Immunization Practices recommended shared clinical decision-making (SCDM) for HPV vaccination among unvaccinated adults aged 27–45 years (i.e., mid-adult). However, the implementation of this recommendation is challenging. This study assessed a decision tool, HPV Decide, designed to facilitate SCDM for mid-adult HPV vaccination. We used exploratory sequential mixed methods to gather stak...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...
The timing of biological events, known as phenology, plays a key role in shaping ecosystem dynamics, and climate change can significantly alter these timings. The Gulf of Maine on the Northeast U.S. Shelf is vulnerable to warming temperatures and other climate impacts, which could affect the distribution and production of plankton species sensitive to phenological shifts. In this study, we apply a novel data‐driven modeling ap...
Coastal water level information is crucial for understanding flood occurrences and changing risks. Here, we validate the preliminary version (0.9) of NOAA’s Coastal Ocean Reanalysis (CORA), which is a 43-year reanalysis (1979–2021) of hourly coastal water levels for the Gulf of Mexico and Atlantic Ocean (i.e., the Gulf and East Coast region, or GEC). CORA-GEC v0.9 was conducted by the Renaissance Computing Institute using the...
Damage to tropical forests caused by cyclones is driven by wind speed but mediated by topographical exposure and tree characteristicsNARA Subscribed
Each year, an average of 45 tropical cyclones affect coastal areas and potentially impact forests. The proportion of the most intense cyclones has increased over the past four decades and is predicted to continue to do so. Yet, it remains uncertain how topographical exposure and tree characteristics can mediate the damage caused by increasing wind speed. Here, we compiled empirical data on the damage caused by 11 cyclones occu...
Industrialized environments, despite benefits such as higher levels of formal education and lower rates of infections, can also have pernicious impacts upon brain atrophy. Partly for this reason, comparing age-related brain volume trajectories between industrialized and non-industrialized populations can help to suggest lifestyle correlates of brain health. The Tsimane, indigenous to the Bolivian Amazon, derive their subsisten...
Realistic representation of monthly sea level anomalies in coastal regions has been a challenge for global ocean reanalyses. This is especially the case in coastal regions where sea levels are influenced by western boundary currents such as near the U.S. Atlantic Coast and the Gulf of Mexico. For these regions, most ocean reanalyses compare poorly to observations. Problems in reanalyses include errors in data assimilation and...
Shape from spectraNARA Subscribed
Sea level rise is increasing the frequency of high tide flooding in coastal communities across the United States. Although the occurrence and severity of high-tide flooding will continue to increase, skillful prediction of high tide flooding on monthly-to-annual time horizons is lacking in most regions. Here, we present an approach to predict the daily likelihood of high tide flooding at coastal locations throughout the U.S. u...