Chronic visceral pain is a persistent and debilitating condition arising from dysfunction or sensitization of the visceral organs and their associated nervous pathways. Increasing evidence suggests that imbalances in central nervous system function play an essential role in the progression of visceral pain, but the exact mechanisms underlying the neural circuitry and molecular targets remain largely unexplored. In the present...

There is a lack of continuous distribution of reef facies in carbonate gentle slopes, which is accompanied by pronounced reservoir heterogeneity and ambiguous development patterns. This complexity necessitates a detailed analysis of sedimentary microfacies and their changing trends to effectively delineate favorable facies zones for resource exploration and development. Previous studies on the sedimentary facies of the Hartha...

Irritable bowel syndrome (IBS) is a common functional bowel disorder characterized by abdominal pain and visceral hypersensitivity. Reducing visceral hypersensitivity is the key to effectively relieving abdominal pain in IBS. Increasing evidence has confirmed that the thalamic nucleus reuniens (Re) and 5-hydroxytryptamine (5-HT) neurotransmitter system play an important role in the development of colorectal visceral pain, wher...