The poor efficacy of chemotherapy for glioma is mainly due to the difficulty of drug penetration through the blood–brain barrier (BBB), as well as the difficulty of drug concentration in the tumor tissue to reach the effective therapeutic level. The emerging tumor-targeted delivery technology can facilitate the precise enrichment of drugs in the tumor site. Apolipoprotein E (ApoE(159–167) 2 ) binds to low-density lipoprotein r...

Under accelerating coastal eutrophication, disentangling the relative roles of light limitation and nitrogen enrichment is essential for diagnosing seagrass decline. We conducted a fully crossed light × ammonium experiment using intact Zostera marina cores from Guzhenkou Bay (4 irradiance levels: 180, 90.6, 17, 0 μmol photons m -2 s -1 ; 4 NH 4 Cl levels: 0, 25, 50, 100 μmol L -1 ; 5 weeks; 16 units; no within-cell replication...

Global expansion of cyanobacterial harmful algal blooms, driven by anthropogenic nutrient loading and climate change, poses escalating threats to water security. While altered precipitation regimes are recognized as critical climate multipliers, their hierarchical controls on cyanobacterial harmful algal bloom dynamics remain poorly quantified, particularly in stratified reservoirs. Here, we integrate a 60‐yr (1961–2020) trend...