Irritable bowel syndrome (IBS) is a gut-brain disorder of multifactorial origin. Evidence of disturbed serotonergic function in IBS accumulated for the 5-HT 3 receptor family. 5-HT 3 Rs are encoded by HTR3 genes and control GI function, and peristalsis and secretion, in particular. Moreover, 5-HT 3 R antagonists are beneficial in the treatment of diarrhea predominant IBS (IBS-D). We previously reported on functionally relevant...

The significance of SHANK proteins in human behaviour is evidenced by the wide spectrum of neuropsychiatric disorders in patients with SHANK mutations and the variety of behavioural impairments of Shank knockout mouse lines. Differentially expressed SHANK isoforms might explain this complexity. The analysis of three conventional and seven conditional Shank2 mouse lines showed that the type of SHANK2 mutation critically determi...