Antimicrobial resistance (AMR) affects multiple fields, including medicine, pharmacy, food safety, and animal husbandry, and poses a major threat to public health and economic development. Staphylococcus aureus has emerged as one of the most critical bacterial pathogens due to its widespread prevalence and significant genetic plasticity. This review outlines currently approved small-molecule drugs for clinical use and their me...

The occurrence and development of tumors rely on the nutritional supply from blood vessels, which also serve as the main pathway for tumor metastasis. Inhibiting angiogenesis is one of the main strategies for cancer treatments. Chiral drugs, encouraged and inspired by chiral natural products, make up a major portion of marketed drugs. However, as an important source for synthetic chemistry and drug discovery, the counterpart o...

As one of the common malignancies that threaten human life, bladder cancer occurs frequently with a high mortality rate in the world, due to its invasion, recurrence and drug resistance. Natural products from marine microorganisms are becoming the hotspots in discovery of new candidate drug entities, especially in the area of cancer. Brefeldin A (BFA) is a natural Arf-GEFs inhibitor, but due to the low aqueous solubility, stro...