Medium spiny neurons (MSNs) in the striatum, which can be divided into D1 and D2 MSNs, originate from the lateral ganglionic eminence (LGE). Previously, we reported that Six3 is a downstream target of Sp8/Sp9 in the transcriptional regulatory cascade of D2 MSN development and that conditionally knocking out Six3 leads to a severe loss of D2 MSNs. Here, we showed that Six3 mainly functions in D2 MSN precursor cells and graduall...

Mouse cortical radial glial cells (RGCs) are primary neural stem cells that give rise to cortical oligodendrocytes, astrocytes, and olfactory bulb (OB) GABAergic interneurons in late embryogenesis. There are fundamental gaps in understanding how these diverse cell subtypes are generated. Here, by combining single-cell RNA-Seq with intersectional lineage analyses, we show that beginning at around E16.5, neocortical RGCs start t...

The dry‐wet climate conditions of an area are mainly determined by the water input (e.g., precipitation, P) and output (e.g., potential evapotranspiration, PET). Based on three dry‐wet indices and the differential equation, this study designed a new attribution method to quantify the contributions of P and PET to the dry‐wet change, so as to determine the dominant factors of the dry‐wet change over whole China (CHINA) and vari...