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Pendrin inhibitor PDSinh-C01 reverses salt-sensitive hypertension and metabolic acidosis in the 5/6 nephrectomy rat modelNARA Subscribed
Pharmacological inhibition of the chloride-bicarbonate exchanger pendrin with PDSinh-C01 potentiates the diuretic action of furosemide in healthy mice. Because pendrin contributes to acid-base regulation and blood pressure control, it may represent an attractive therapeutic target in chronic kidney disease (CKD). We investigated whether this pendrin inhibitor improves metabolic acidosis and salt-sensitive hypertension in the 5...
Deployment of long-term, continuously recording passive-acoustic sensors in the ocean can provide insights into sound sources related to ocean dynamics, air–sea interactions, and biologic and human activities, all which contribute to shaping ocean soundscapes. In the polar regions, the changing ocean climate likely contributes to seasonal and long-term variation in cryogenic sounds, adding to the complexity of these soundscape...
A weighted ensemble (WE) method is revisited and employed to issue an improved seasonal probability of precipitation (POP) forecast. Nine boreal summer time seasonal precipitation hindcasts obtained from the APEC (Asia‐Pacific Economic Cooperation) Climate Center (APCC) multi‐model ensemble system are used to assess the suitability of the WE approach for seasonal POP predictions. Owing to its performance‐based selective nature...
Distinct expression of GnRH genes in the red seabream brainNARA Subscribed
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