The first Vascular Contributions to Cognitive Impairment and Dementia (VCID) Workshop, held on May12-16, 2025 at The Jackson Laboratory, provided scientific content and career development training in the latest developments in VCID and Alzheimer’s Disease (AD) and related dementia (ADRD). The Workshop aimed to foster interdisciplinary collaborations and empower the next generation of diverse scientists to advance ADRD research...

Background Currently, no single biomarker can reliably identify preclinical Alzheimer’s disease (AD), particularly at or before the mild cognitive impairment (MCI) stage. Given the heterogeneity of MCI, integrative approaches are needed to improve early risk stratification. Objectives (i) To derive robust latent cognitive components from a multicenter, clinically defined MCI cohort using principal component analysis (PCA); (ii...

To obtain comprehensive insight into metabolic changes in potato seed tubers during storage and to identify patterns associated with physiological ageing, we analysed tuber metabolite composition using untargeted metabolomics based on gas and liquid chromatography-mass spectrometry (GC–MS and LC–MS). During two seasons, seed tubers of four contrasting cultivars (Agria, Festien, Innovator, and Lady Claire) were produced in a si...

The recreational fishery for pollack ( Pollachius pollachius ) in the northeast Atlantic is impacted by the species' high sensitivity to barotrauma. When captured at depth and brought to the surface, gas expansion within the peritoneal cavity can cause a variety of injuries and hinder release. Via an experimental weighted cage, this study evaluated the efficacy of releasing Pollack at depth as a barotrauma mitigation strategy....

Enhancing protein stability while maintaining activity is a long-standing challenge in protein engineering, as modifications that benefit one property often compromise another. In this study, we leveraged a computational design strategy, CamSol Combination, to make a first step to improve the stability of purple acid phosphatase (PAP), a metalloprotein known for its distinctive pink color. PAP serves as a challenging model for...

Purpose To study the incidence and subtype of breast cancer in relation to incident and prevalent statin use in a contemporary Swedish prospective cohort, The Karolinska Mammography Project for Risk Prediction of Breast Cancer, KARMA. Methods A total of 35,315 postmenopausal women attending mammography and included in the KARMA cohort (Jan 2011–March 2013) with data on statin use and potential confounders were studied. During...

Chemical exposures are poorly characterized in Central America, where chronic kidney disease of uncertain etiology (CKDu) is a leading cause of death. Most research evaluates occupational exposures in adults, yet early-life exposures remain understudied. We used silicone wristband passive samplers to characterize exposure to over 1,500 chemicals among Nicaraguan adolescents ( n = 80) residing in CKD high-risk communities but n...

Aim The Indo‐Pacific is the world's largest marine biogeographic region. It is characterised by different degrees of connectivity among its subregions and harbours the majority of demosponge species currently known to science. Comparisons between regional sponge faunas have been undertaken in the past, mostly based on morphological species identification. The Sponge Barcoding Project, in tandem with regional DNA taxonomy campa...

Aim Animal movements are a fundamental process affecting communities and ecosystems. Quantifying habitat selection across species and habitats is key for understanding how animals respond to environmental change. Currently, we lack comparative studies that examine how habitat selection varies across species traits and landscapes. We aim to quantify global patterns of habitat selection to help understand the fundamental drivers...

Algal dynamics are fundamental drivers of lotic ecosystem processes. Although rivers tend to be heterotrophic and have low standing stocks of autotrophic biomass, filamentous algae can cause nuisance algal blooms that alter the structure of the autotrophic assemblage. Still, the influence of these blooms on ecosystem processes can be variable. Here, we examined the structural and functional contribution of filamentous and epil...

Rapid warming could drastically alter host–parasite relationships, which is especially important for fisheries crucial to human nutrition and economic livelihoods, yet we lack a synthetic understanding of how warming influences parasite‐induced mortality in these systems. We conducted a meta‐analysis using 266 effect sizes from 52 empirical papers on harvested aquatic species and determined the relationship between parasite‐in...