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Targeting Mitochondrial Dysfunction in Acute Organophosphate Toxicity: A Preliminary Evaluation of Cyclosporine ANARA Subscribed
Background Organophosphate (OP) compounds are widely used agricultural chemicals that pose significant public health and chemical threat concerns due to their neurotoxic effects. Although OP toxicity has classically been attributed to acetylcholinesterase inhibition and cholinergic crisis, emerging evidence suggests mitochondrial dysfunction may represent an additional and clinically relevant mechanism of injury. Experimental...
Effects of lumbar disc injury and nociception on trunk motor control during rat locomotionNARA Subscribed
Intervertebral disc (IVD) injury is a major cause of low-back pain and can lead to structural deficits and mechanical instability. When the IVD is compromised, neuromuscular compensation by paraspinal muscles, such as the multifidus (MF) and longissimus (ML), is critical for maintaining spine stability. However, it is unknown how IVD injury and its interaction with nociception affect neuromuscular control. This study assessed...
Precision measurement of the Ds*+-Ds+ meson mass differenceNARA Subscribed
Brain macrostructure correlates of financial altruism in older adults without dementiaNARA Subscribed
Greater financial altruism (i.e., the tendency to give money to an anonymous individual) has been previously associated with poorer performance on neuropsychological tests sensitive to cognitive changes occurring in early Alzheimer’s disease (AD). While these findings provide initial support for the idea that financial altruism may be associated with early AD-related brain changes, no study has used MRI to investigate structur...
Earthworms Enhance Global Soil Carbon Storage Through Microbial–Mineral StabilizationNARA Subscribed
Earthworms play a dual role in the global carbon cycle: they accelerate organic matter decomposition yet are often associated with greater soil organic carbon (SOC) storage. However, uncertainty regarding the mechanisms and magnitudes through which earthworms concurrently influence SOC mineralization and stabilization has limited the integration of soil fauna into carbon models. Here, we synthesize 696 paired observations from...