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Plant nutrient elements defined from the plant’s perspectiveNARA Subscribed
Localization of dendritic cells and T cells within the tumor microenvironment in different types of skin cancerNARA Subscribed
Immunophenotyping of tumor-infiltrating immune cells is increasingly important for understanding the tumor microenvironment (TME), particularly in the diagnosis and treatment of skin cancer. CD1a + dendritic cells (DC) initiate T cell activation by presenting tumor antigens, while T cells directly target tumor cells. Analyzing their spatial distribution in different types of skin cancer can provide insights into immune respons...
Detection of Eco‐Evolutionary Dynamics in Communities Using Joint Species Distribution ModelsNARA Subscribed
Biodiversity at the metacommunity scale is typically influenced by numerous environmental, spatial, biotic, and stochastic factors. These factors can simultaneously impact evolution in individual species, due to site‐varying local selection pressures and the impact of connectivity for gene flow and genetic drift. Joint species distribution models (JSDMs) can estimate the relative impacts of environmental, spatial, biotic, and...
A physically and mentally active lifestyle relates to younger brain and cognitive ageNARA Subscribed
Resistance to age-related pathological changes (brain maintenance), including Alzheimer’s disease, cerebrovascular disease, and neurodegeneration may promote cognitive resilience in aging. However, how lifestyle and health profiles relate to successful cognitive and brain aging remains poorly understood. In a novel, deeply phenotyped cohort of 211 cognitively unimpaired older adults (age = 71.0 ± 7.4 years, 46% female), we cha...
In this study, hindcasts from eight Copernicus Climate Change Service (C3S) and three North American Multi‐Model Ensemble (NMME) operational seasonal forecast systems, based on dynamical climate models, are employed to investigate the influence of the South Atlantic Ocean Dipole (SAOD) on the predictive skill of Central Africa (CA) rainfall. The focus is primarily on the June–July–August season for 1993–2016. The findings reve...
Regulating cancer risk prediction: legal considerations and stakeholder perspectives on the Canadian contextNARA Subscribed
Risk prediction models hold great promise to reduce the impact of cancer in society through advanced warning of risk and improved preventative modalities. These models are evolving and becoming more complex, increasingly integrating genetic screening data and polygenic risk scores as well as calculating risk for multiple types of a disease. However, unclear regulatory compliance requirements applicable to these models raise si...
There is an urgent need for countries to transition their national food and land-use systems toward food and nutritional security, climate stability, and environmental integrity. How can countries satisfy their demands while jointly delivering the required transformative change to achieve global sustainability targets? Here, we present a collaborative approach developed with the FABLE—Food, Agriculture, Biodiversity, Land, and...
A large frozen debris avalanche entraining warming permafrost ground—the June 2021 Assapaat landslide, West GreenlandNARA Subscribed
A large landslide (frozen debris avalanche) occurred at Assapaat on the south coast of the Nuussuaq Peninsula in Central West Greenland on June 13, 2021, at 04:04 local time. We present a compilation of available data from field observations, photos, remote sensing, and seismic monitoring to describe the event. Analysis of these data in combination with an analysis of pre- and post-failure digital elevation models results in t...
Genetic architecture of fusarium head blight disease resistance and associated traits in Nordic spring wheatNARA Subscribed
Key message This study identified a significant number of QTL that are associated with FHB disease resistance in NMBU spring wheat panel by conducting genome-wide association study. Abstract Fusarium head blight (FHB) is a widely known devastating disease of wheat caused by Fusarium graminearum and other Fusarium species. FHB resistance is quantitative, highly complex and divided into several resistance types. Quantitative tra...
Calorie restriction confers post-ischemic neuroprotection, when administered in a defined time window before ischemic stroke. How a hypocaloric diet influences stroke recovery when initiated after stroke has not been investigated. Male C57BL6/j mice were exposed to transient intraluminal middle cerebral artery occlusion. Immediately post-ischemia, mice were randomized to two groups receiving moderately hypocaloric (2286 kcal/k...
Extracellular Vesicles Derived from Neural Progenitor Cells––a Preclinical Evaluation for Stroke Treatment in MiceNARA Subscribed
Stem cells such as mesenchymal stem cells (MSCs) enhance neurological recovery in preclinical stroke models by secreting extracellular vesicles (EVs). Since previous reports have focused on the application of MSC-EVs only, the role of the most suitable host cell for EV enrichment and preclinical stroke treatment remains elusive. The present study aimed to evaluate the therapeutic potential of EVs derived from neural progenitor...
Mammalian carnivores are considered a key group in maintaining ecological health and can indicate potential ecological integrity in landscapes where they occur. Carnivores also hold high conservation value and their habitat requirements can guide management and conservation plans. The order Carnivora has 84 species from 8 families in the Neotropical region: Canidae; Felidae; Mephitidae; Mustelidae; Otariidae; Phocidae; Procyon...
Compromised Hippocampal Neuroplasticity in the Interferon-α and Toll-like Receptor-3 Activation-Induced Mouse Depression ModelNARA Subscribed
Disrupted neuronal plasticity due to subtle inflammation is considered to play a fundamental role in the pathogenesis of major depressive disorder. Interferon-α (IFN-α) potentiates immune responses against viral pathogens that induce toll-like receptor-3 (TLR3) activation but evokes severe major depressive disorder in humans by mechanisms that remain insufficiently described. By using a previously established mouse model of de...
Selection for multiple traits is a highly challenging task for breeders due to potential unfavorable associations between characters. Fusarium head blight FHB, being one of the most relevant diseases affecting durum wheat frequently shows in this respect an unfavorable correlation with morpho-agronomical traits like plant height (PH) and heading date (HD). In this study, we used a cross-validation scheme to assess the predicti...