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Live-cell imaging reveals decreased cAMP in a PFE-associated c.1050-3C>G PTH1R cell modelNARA Subscribed
Primary failure of eruption (PFE) is a rare autosomal disorder provoked by heterozygous mutations in the parathyroid hormone receptor 1 ( PTH1R ) gene. PTH1R is a G protein-coupled receptor (GPCR) which regulates intracellular signaling molecules like cAMP. By using CRISPR/Cas9, the pathogenic PTH1R variant, c.1050-3C>G, was introduced into the periodontal ligament (PDL-hTERT) cell line to investigate molecular mechanisms in a...
Diet- and trophic studies involving whales are often challenging, particularly for deep-diving species that are difficult to observe while feeding. Recently, environmental DNA (eDNA) techniques relying on water samples have been increasingly used to describe biodiversity patterns in marine ecosystems. These methods also show promise for examining trophic interactions and identifying potential prey for whales. Here, we used eDN...
Ecosystem Metabolic Rates Estimated from Diel Oxygen Measurements in Two Subtropical EstuariesNARA Subscribed
Subtropical estuaries worldwide are facing increasing pressure from human population growth, development, and climate change. Carbon is a useful currency for understanding how estuaries respond to these pressures and yet relatively little is known about carbon cycling in subtropical estuaries. Here we compute gross primary production (GPP), ecosystem respiration (ER), and net ecosystem production (NEP) from the diurnal cycle i...
Soil access is an equity issue for urban climate resilienceNARA Subscribed
Increase of collagen content and reorganization characterizes fibrosis but quantifying the latter remains challenging. Spatially complex structures are often analyzed via the fractal dimension; however, established methods for calculating this quantity either provide a single dimension for an entire object or a spatially distributed dimension that only considers binary images. These neglect valuable information related to coll...
Cadmium Reduction in Spring Wheat: Root Exudate Composition Affects Cd Partitioning Between Roots and ShootsNARA Subscribed
Cadmium (Cd) in cereals is one of the major sources of Cd intake by human diets, and solutions to reduce Cd concentrations in wheat still need to be developed. Plant breeding, by selecting low-Cd varieties, can be an important tool to reduce Cd in crops. Knowing the genotypic variation in Cd accumulation and furthering our understanding of the impact of root exudates composition on Cd accumulation in crops may provide valuable...
Cytochrome P450 monooxygenases (CYPs) are important tools for regio- and stereoselective oxidation of target molecules or engineering of metabolic pathways. Functional heterologous expression of eukaryotic CYPs is often problematic due to their dependency on the specific redox partner and the necessity of correct association with the membranes for displaying enzymatic activity. Plant hosts offer advantages of accessibility of...
ForC: a global database of forest carbon stocks and fluxesNARA Subscribed
Forests play an influential role in the global carbon (C) cycle, storing roughly half of terrestrial C and annually exchanging with the atmosphere more than five times the carbon dioxide ( CO 2 ) emitted by anthropogenic activities. Yet, scaling up from field‐based measurements of forest C stocks and fluxes to understand global scale C cycling and its climate sensitivity remains an important challenge. Tens of thousands of for...