Understanding the links between metabolism, ageing, and age-related phenotypes may clarify the role of ageing in disease onset and improve risk prediction. We conducted a cross-cohort assessment of biological age using broad-spectrum LC–MS metabolomics of 3,686 plasma samples in 2,295 participants, aged 20–89, from the UK Airwave study ( N = 960) and the Irish Longitudinal Study of Ageing ( N = 1,335). The nucleoside N 2 ,N 2...

Starch was extracted from jackfruit and durian seeds using distilled water and alkaline methods, with higher yields obtained via distilled water (27.7% and 18.4%, respectively). The extracted starches were cationized using 3-chloro-2-hydroxypropyltrimethylammonium chloride (CTA) to enhance coagulation performance. Characterization confirmed successful functionalization, with particle size increases of 32% (jackfruit) and 45% (...

Wood-boring ambrosia beetles and their offspring obligately depend on cultivated fungi that they maintain within host trees. Stressed trees produce at least two potent antimicrobials, ethanol and acetic acid, which typically suppress the growth of most fungi. Ethanol facilitates the growth of ambrosia beetles’ fungal mutualists and thus aids in host colonization; however, acetic acid’s effects are unknown. Here, we evaluated t...

The Asia region harbors exceptional chondrichthyan (shark, ray, and chimaera) diversity but faces intense fishing pressure. The Important Shark and Ray Areas (ISRA) process provides a collaborative, evidence-based framework to identify critical habitats and inform spatial management. We assessed ISRAs across the Bay of Bengal, Southeast Asia, and the Northwest Pacific to characterize their extent, ecological significance, and...

Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in the aging population. Although frailty has been recognized as a potential risk factor, previous studies relying on static assessments cannot capture its dynamic nature. This study aims to prospectively evaluate the association between dynamic frailty trajectories and incident AMD. The baseline cohort included 462,573 UK Biobank participant...

Background Chronic pericarditis is associated with significant cardiovascular morbidity, including atrial fibrillation (AF), heart failure (HF), and stroke. Colchicine is widely used in pericarditis management for its anti-inflammatory effects, but its impact on arrhythmias and other cardiovascular outcomes remains uncertain. Methods We conducted a retrospective observational cohort study using the TriNetX global federated res...

Background Breast cancer survivors have an increased risk of second primary cancers (SPCs), the role of county-level socioeconomic status and rurality—factors that may influence access to treatment, surveillance, and preventive care—remains understudied. Methods We identified 721,957 women with localized/regional first primary breast cancer who survived ≥ 1 year in 17 Surveillance, Epidemiology, and End Results registries (200...