Metabolic dysfunction-associated steatotic liver disease (MASLD), marked by excess fat in the liver, has become the most prevalent chronic liver disease worldwide, affecting over 30% of adults. Its advanced form, metabolic dysfunction associated steatohepatitis (MASH), includes liver ballooning, and inflammation, and can progress to cirrhosis and hepatocellular carcinoma (HCC). Despite the increasing burden, effective pharmaco...

Calsequestrin 2 (CASQ2) has emerged as a central sensor and modulator of calcium (Ca 2+ ) dynamics in sarcoplasmic reticulum (SR), influencing both health and disease. This review explores the molecular architecture and multifunctional roles of CASQ2, beginning with its domain organization and Ca 2+ -binding properties and detecting how its folding and supramolecular assembly modulate Ca 2+ storage and release within cardiac m...