HENRY LIN results 48
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Outbreak of Salmonella Typhimurium ST19 linked to passerine birds and cats in Norway, March to July 2024NARA Subscribed
Purpose In June 2024, a genomic cluster of seven Salmonella Typhimurium - sequence type 19, and cluster type 21092 - was detected in Norway, triggering a national outbreak investigation. Methods Information about new cases was collected from the Norwegian Surveillance System for Communicable Diseases and the database at the National Reference Laboratory for Enteropathogenic Bacteria (NRL) at the Norwegian Institute of Public H...
Genetic mapping of novel QTL for seed protein stability in food-grade soybean (Glycine max)NARA Subscribed
Key message Two novel quantitative trait loci associated with soybean protein content stability were identified on chromosomes 10 and 18. Haplotype analysis showed these to significantly improve stability without protein content penalty. Abstract Soybean seed protein content is a complex physiological trait under polygenic control and significant genotype by environment interaction. Protein content is largely influenced by amb...
Key message A major QTL for sucrose content was mapped on chromosome 8 in PI 506593. The novel genetic variants and candidate genes were further identified within the major QTL. Abstract Sucrose in soybean [ Glycine max (L.) Merr.] contribute to animal feed efficiency and natural sweetness of soy products. Thus, identifying novel genetic resources, such as quantitative trait loci (QTL), associated with sucrose content in soybe...
Determinants of microbiome composition: Insights from free‐ranging hybrid zebras ( Equus quagga × grevyi )NARA Subscribed
The composition of mammalian gut microbiomes is highly conserved within species, yet the mechanisms by which microbiome composition is transmitted and maintained within lineages of wild animals remain unclear. Mutually compatible hypotheses exist, including that microbiome fidelity results from inherited dietary habits, shared environmental exposure, morphophysiological filtering and/or maternal effects. Interspecific hybrids...
Key message This review provides a comprehensive atlas of QTLs, genes, and alleles conferring resistance to 28 important diseases in all major soybean production regions in the world. Abstract Breeding disease-resistant soybean [ Glycine max (L.) Merr.] varieties is a common goal for soybean breeding programs to ensure the sustainability and growth of soybean production worldwide. However, due to global climate change, soybean...
Deafness, the most frequent sensory deficit in humans, is extremely heterogeneous with hundreds of genes involved. Clinical and genetic analyses of an extended consanguineous family with pre-lingual, moderate-to-profound autosomal recessive sensorineural hearing loss, allowed us to identify CLRN2, encoding a tetraspan protein, as a new deafness gene. Homozygosity mapping followed by exome sequencing identified a 14.96 Mb locus...
Identification of PP2A and S6 Kinase as Modifiers of Leucine-Rich Repeat Kinase-Induced NeurotoxicityNARA Subscribed
Mutations in LRRK2 are currently recognized as the most common monogenetic cause of Parkinsonism. The elevation of kinase activity of LRRK2 that frequently accompanies its mutations is widely thought to contribute to its toxicity. Accordingly, many groups have developed LRRK2-specific kinase inhibitors as a potential therapeutic strategy. Given that protein phosphorylation is a reversible event, we sought to elucidate the phos...
Climate‐induced changes in the suitable habitat of cold‐water corals and commercially important deep‐sea fishes in the North AtlanticNARA Subscribed
The deep sea plays a critical role in global climate regulation through uptake and storage of heat and carbon dioxide. However, this regulating service causes warming, acidification and deoxygenation of deep waters, leading to decreased food availability at the seafloor. These changes and their projections are likely to affect productivity, biodiversity and distributions of deep‐sea fauna, thereby compromising key ecosystem se...