This study presents a new 3D coupled damage-plasticity model with energy-based regularisation in Smoothed Particle Hydrodynamics (SPH) for modelling fractured quasi-brittle rocks. The model accounts for energy dissipation in both the tensile and compressive regimes by distinctly separating damage evolution in tension and compression. A semi-analytical solution is introduced to derive damage evolution parameters linked to energ...

The sustainability of social–ecological systems within river deltas globally is in question as rapid development and environmental change trigger “negative” or “positive” tipping points depending on actors’ perspectives, e.g. regime shift from abundant sediment deposition to sediment shortage, agricultural sustainability to agricultural collapse or shift from rural to urban land use. Using a systematic review of the literature...

Background We have observed an increased expression of negative markers in some clinical-grade, xeno- and serum-free cultured adipose-derived mesenchymal stem/stromal cell (ADMSC) samples. It gave rise to concern that xeno- and serum-free conditions might have unexpected effects on human ADMSCs. This study aims to test this hypothesis for two xeno- and serum-free media, PowerStem MSC1 media (PS) and StemMACS MSC Expansion Medi...