Marine heatwaves repeatedly trigger summer mortality of the farmed Pacific oyster (Crassostrea gigas), forcing its haemocytes to reprogramme metabolism under thermal stress. The metabolic nodes governing this adaptation remain poorly defined. Integrating publicly available transcriptomics, single-cell analysis, enzyme inhibition, and molecular dynamics simulation, we identify argininosuccinate synthetase (CgASS) as a key node...

Sodium sulfite (SS) is a common food additive that is widely absorbed and distributed throughout the body, but its excessive intake has been linked to adverse health effects. Here, we investigate the impact of chronic SS exposure on bone tissue and the underlying mechanisms. Using a mouse model, we demonstrate that prolonged SS exposure induces significant bone loss, which correlates with alterations in ferroptosis-related mar...