Marine heatwaves repeatedly trigger summer mortality of the farmed Pacific oyster (Crassostrea gigas), forcing its haemocytes to reprogramme metabolism under thermal stress. The metabolic nodes governing this adaptation remain poorly defined. Integrating publicly available transcriptomics, single-cell analysis, enzyme inhibition, and molecular dynamics simulation, we identify argininosuccinate synthetase (CgASS) as a key node...

High-altitude hypoxia (HH) significantly affects mammalian physiological functions, especially sleep rhythms, anxiety-like behavior, and neuroinflammation. In this study, adult male Sprague-Dawley rats were randomly assigned to five groups: Control, HH, HH with low-dose dexmedetomidine (Dex), HH with high-dose Dex, and Control with Dex. Rats were exposed to a simulated 6000-meter altitude for 7 days. Behavioral tests, enzyme-l...

The vortex-induced vibration (VIV) dynamics of commercial-scale deep-sea mining risers with complex component arrangements (pumps, buffer stations, buoyancy modules) remain insufficiently explored, especially for 6000 m systems with nonlinear tension. This study investigates VIV control strategy by adjusting tension for a nonlinear riser system using the Iwan-Blevins wake oscillator model integrated with Morison equation-based...