Hamid Ceylan results 11
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Doxorubicin (DOX) is an effective chemotherapeutic agent; however, its clinical use is limited due to dose-dependent toxicities. This study aimed to investigate the potential protective effect of tannic acid (TA), a natural polyphenol with antioxidant properties, against DOX-induced alterations in oxidative pentose phosphate pathway (PPP) enzymes in rat lung tissue. Male rats were treated with DOX, TA, or a combination of both...
Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder characterized by complex molecular alterations across multiple brain regions. In this study, we applied an integrative systems-level framework combining multi-region transcriptomic analysis, protein–protein interaction (PPI) network topology, machine learning–based validation, and in silico approaches to identify robust and pharmacologically relevant molec...
Investigation of the effects of monosodium glutamate and tannic acid on the glutathione and thioredoxin systems in the liver of ratsNARA Subscribed
While there is no conclusive evidence that monosodium glutamate (MSG, a food additive) directly causes liver cancer in humans, certain studies suggest a potential link between MSG-induced liver injury and cancer development. This study aimed to evaluate the protective effect of tannic acid (TA, a natural polyphenol) against MSG-induced hepatotoxicity through the glutathione and thioredoxin systems. Twenty-four rats were random...
Investigation of the effect of tannic acid on doxorubicin-ınduced testicular damage and functions in a rat modelNARA Subscribed
Reproductive and testicular toxicity is one of the most important side effects of doxorubicin (DOX), a chemotherapy drug. In our study, we investigated the ameliorative effect of tannic acid (TA), a polyphenol, against DOX-induced testicular and reproductive toxicity in rats. For this purpose, rats divided into four groups ( n = 5 each). Rats were treated with DOX cumulatively 30 mg/kg (5 mg/kg by six equal injections) for 2 w...
Bioinformatics-Based Discovery of Therapeutic Targets in Cadmium-Induced Lung Adenocarcinoma: The Role of OxyresveratrolNARA Subscribed
In this study, we establish a comprehensive bioinformatic and experimental platform for revealing the molecular bases of cadmium (Cd)-induced lung adenocarcinoma (LUAD) and the therapeutic efficacy of the natural polyphenol oxyresveratrol (O-RES) against this disease. A total of 116 differentially expressed genes (DEGs) were obtained, including 30 upregulated and 86 downregulated obtained by integrating five LUAD-related trans...
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