This research aims to investigate the effect of gemcitabine (GEM) on various activities and functions of macrophages. Phagocytosis, cell autophagy and reactive oxygen species (ROS) were analysed by laser scanning confocal microscope. The cell cycle status and major histocompatibility complex II (MHC-II) expression were examined by flow cytometry. Inflammatory cytokine secretion such as tumour necrosis factor α (TNF-α) and inte...

Joubert syndrome is characterized by unique malformation of the cerebellar vermis. More than thirty Joubert syndrome genes have been identified, including ARL13B . However, its role in cerebellar development remains unexplored. We found that knockdown or knockout of arl13b impaired balance and locomotion in zebrafish larvae. Granule cells were selectively reduced in the corpus cerebelli, a structure homologous to the mammalian...

In the paper, we analyze the climate-related risks of rainstorm floods, droughts and water shortages, high temperatures, and heavy hazes in the Xiongan New Area. A warming and drying trend was seen in Xiongan New Area during 1961–2018, as evidenced by the increase in the number of high-temperature days and the maximum rainfall intensity per hour, a decrease in surface water resources and groundwater levels, a reduction in wind...