Joubert syndrome is characterized by unique malformation of the cerebellar vermis. More than thirty Joubert syndrome genes have been identified, including ARL13B . However, its role in cerebellar development remains unexplored. We found that knockdown or knockout of arl13b impaired balance and locomotion in zebrafish larvae. Granule cells were selectively reduced in the corpus cerebelli, a structure homologous to the mammalian...

In the paper, we analyze the climate-related risks of rainstorm floods, droughts and water shortages, high temperatures, and heavy hazes in the Xiongan New Area. A warming and drying trend was seen in Xiongan New Area during 1961–2018, as evidenced by the increase in the number of high-temperature days and the maximum rainfall intensity per hour, a decrease in surface water resources and groundwater levels, a reduction in wind...

Idiopathic pulmonary fibrosis (IPF) is an agnogenic, rare, and lethal disease, with high mortality and poor prognosis and a median survival time as short as 3 to 5 years after diagnosis. No effective therapeutic drugs are still not available not only in clinical practice, but also in preclinical phases. To better and deeper understand pulmonary fibrosis will provide more effective strategies for therapy. Mounting evidence sugg...