Lanosterol 14-alpha demethylase (CYP51), encoded by the Erg11 gene, is a crucial enzyme in pathogenic fungi. It catalyzes the demethylation of lanosterol to ergosterol, a vital component of fungal cell membranes. Inhibition of CYP51 disrupts ergosterol biosynthesis, compromises membrane integrity, and inhibits fungal growth, making it a key target for antifungal therapy. In this study, we employed a comprehensive computational...

Neuropathic pain is a chronic condition caused by damage or dysfunction in the nervous system. While the spleen may influence neuropathic pain, its role has been poorly understood. This study demonstrates that the spleen plays a crucial role in regulating neuropathic pain through the bed nucleus of the stria terminalis (BNST) - paraventricular nucleus of the hypothalamus (PVN) neural circuit in a chronic constriction injury (C...

For 5 MW floating wind turbines, the load response is significantly affected by wind and rain conditions. In order to reveal the relevant regularity of windblown rain and analyze the load response after being affected by the wind and rain, the rain phase is regarded as a continuous phase to be simulated. The self-compiled solver WARFoam (Wind and Rain Foam) is used to simulate the 5 MW wind turbines under wind and rain conditi...