Loading operations are a crucial part of container terminal activities and play a key role in influencing shoreline operation efficiency. To overcome the challenge of mismatched local ship decisions and global yard decisions during single-vessel operations, which often result in conflicts related to container retrieval in the yard, a novel intelligent decision-making model for stack-yard positioning in full shoreline loading o...

Hereditary angioedema (HAE) due to C1-inhibitor deficiency is a rare, debilitating, genetic disorder characterized by recurrent, unpredictable, attacks of edema. The clinical symptoms of HAE arise from excess bradykinin generation due to dysregulation of the plasma kallikrein-kinin system (KKS). A quantitative systems pharmacology (QSP) model that mechanistically describes the KKS and its role in HAE pathophysiology was develo...