Cardiotoxicity remains the leading driver of drug attrition; however, its prediction remains suboptimal when conventional hERG assays and animal models are used. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) offer a human-relevant alternative that aligns with the CiPA initiative and ICH E14/S7B guidelines. This study validated an integrated platform that combines high-purity hiPSC-CMs with Artificial I...

Background As the prevalence of metabolic dysfunction-associated steatohepatitis (MASH) continues to rise, drug development has accelerated, with growing interest in therapeutic strategies that harness metabolic hormones. Metabolic hormone-based approaches, particularly those originally developed for obesity and diabetes, have shown potential to mitigate MASH. Notably, the glucagon-like peptide-1 receptor (GLP-1R) agonist sema...

Prasiola japonica is a freshwater green alga distributed in Northeast Asia. This study investigated the effects of 70% ethanol extract of P. japonica (Pj-EE) under testosterone-induced hair loss conditions using C57BL/6 mice and human dermal papilla (HDP) cells. Topical application of Pj-EE promoted hair regrowth, increased hair length, and enhanced follicular density and activity in vivo. Pj-EE treatment also partially restor...