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Antibiotics cause significant gut microbiome dysbiosis, particularly when administered orally. This contributes to antimicrobial resistance (AMR) and is associated with myriad health conditions. Novel drug delivery strategies that minimize gut exposure while maintaining therapeutic efficacy are urgently needed. This study aimed to evaluate whether a novel transdermal system could reduce gut microbiome disruption compared to or...
The Genomic Signature of Demographic Decline in a Long‐Distance Migrant in a Range‐Extreme PopulationNARA Subscribed
Migratory birds are inherently vagile, a strategy that may reduce the impacts of habitat loss and fragmentation on genetic diversity. However, specialist resource requirements and range‐edge distribution can counteract these benefits. The European nightjar ( Caprimulgus europaeus ) is a long‐distance migratory bird and resource specialist. Like other long‐distance migrants, nightjar populations have declined across the British...
Multi-step advanced anaerobic digestion (AAD) pretreatment of feedstocks increases biogas yields compared to non-pretreated feedstocks, and is key to the processing of recalcitrant lignocellulosic feedstock to make commercial biogas production more economically viable. Here, we present several low energy and eco-friendly pretreatments to commercially relevant lignocellulosic feedstocks (rye and maize), to increase biomethane y...
Voxel-wise insights into early Alzheimer’s disease pathology progression: the association with APOE and memory declineNARA Subscribed
Longitudinal investigation of the Apolipoprotein E (APOE) genotype’s impact on Alzheimer’s disease (AD) biomarker progression, focusing on amyloid beta (Aβ) accumulation and gray matter (GM) atrophy, integrating cognitive decline and baseline levels. Longitudinal florbetapir-PET and T1-weighted MRI data from 100 cognitively normal (CN) and mild cognitive impaired (MCI) participants both with considerable global Aβ accumulation...
Complementary value of molecular, phenotypic, and functional aging biomarkers in dementia predictionNARA Subscribed
DNA methylation age (MA), brain age (BA), and frailty index (FI) are putative aging biomarkers linked to dementia risk. We investigated their relationship and combined potential for prediction of cognitive impairment and future dementia risk using the ADNI database. Of several MA algorithms, DunedinPACE and GrimAge2, associated with memory, were combined in a composite MA alongside BA and a data-driven FI in predictive analyse...
Damage to tropical forests caused by cyclones is driven by wind speed but mediated by topographical exposure and tree characteristicsNARA Subscribed
Each year, an average of 45 tropical cyclones affect coastal areas and potentially impact forests. The proportion of the most intense cyclones has increased over the past four decades and is predicted to continue to do so. Yet, it remains uncertain how topographical exposure and tree characteristics can mediate the damage caused by increasing wind speed. Here, we compiled empirical data on the damage caused by 11 cyclones occu...
Krill are a direct conduit between primary productivity and recreationally and commercially important higher trophic level species globally. Determining how krill abundance varies with temporal environmental variation is key to understanding their function in coastal-pelagic food webs, as well as applications in fisheries management. We used nine years (2012–19 and 2021) of late spring/early summer hydroacoustic-trawl survey d...
Targeting de novo loss-of-function variants in constrained disease genes improves diagnostic rates in the 100,000 Genomes ProjectNARA Subscribed
Background Genome sequencing was first offered clinically in the UK through the 100,000 Genomes Project (100KGP). Analysis was restricted to predefined gene panels associated with the patient’s phenotype. However, panels rely on clearly characterised phenotypes and risk missing diagnoses outside of the panel(s) applied. We propose a complementary method to rapidly identify pathogenic variants, including those missed by 100KGP...